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Literature summary for 3.4.24.B3 extracted from

  • Noel, A.; Boulay, A.; Kebers, F.; Kannan, R.; Hajitou, A.; Calberg-Bacq, C.M.; Basset, P.; Rio, M.C.; Foidart, J.M.
    Demonstration in vivo that stromelysin-3 functions through its proteolytic activity (2000), Oncogene, 19, 1605-1612.
    View publication on PubMed
Search for more literature for 3.4.24.B3

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of wild-type and mutant E220A in Escherichia coli, expression of wild-type and inactive enzyme in MCF7 carcinoma cells Mus musculus
overexpression of wild-type and mutant E220A in Escherichia coli, expression of wild-type and inactive enzyme in MCF7 carcinoma cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
E216A site-directed mutagenesis, exchange of a residue in the zinc-binding catalytic domain, inactive Homo sapiens
E220A site-directed mutagenesis, exchange of a residue in the zinc-binding catalytic domain, inactive Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
matrix metalloprotease inhibitor TIMP-2
-
 Homo sapiens
matrix metalloprotease inhibitor TIMP-2
-
 Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protein + H2O Mus musculus the enzyme promotes and modulates tumor progression peptides
-
 ?
protein + H2O Homo sapiens the enzyme promotes and modulates tumor progression peptides
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification
-
 Mus musculus
proteolytic modification
-
 Homo sapiens

Renatured (Commentary)

Renatured (Comment) Organism
refolding of recombinant enzyme from inclusion bodies after overexpression in Escherichia coli Mus musculus
refolding of recombinant enzyme from inclusion bodies after overexpression in Escherichia coli Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha1-protease inhibitor + H2O
-
 Mus musculus ?
-
 ?
alpha1-protease inhibitor + H2O
-
 Homo sapiens ?
-
 ?
protein + H2O
-
 Mus musculus peptides
-
 ?
protein + H2O
-
 Homo sapiens peptides
-
 ?
protein + H2O the enzyme promotes and modulates tumor progression Mus musculus peptides
-
 ?
protein + H2O the enzyme promotes and modulates tumor progression Homo sapiens peptides
-
 ?

Synonyms

Synonyms Comment Organism
M10.007 Merops-ID Mus musculus
M10.007 Merops-ID Homo sapiens
matrix metalloproteinase-11
-
 Mus musculus
matrix metalloproteinase-11
-
 Homo sapiens
matrixin 11
-
 Mus musculus
matrixin 11
-
 Homo sapiens
MMP-11
-
 Mus musculus
MMP-11
-
 Homo sapiens